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A Harvard Medical School Affiliate
Welcome to the Joslin Research Website
Joslin Investigator:
Allison B. Goldfine, M.D.
Investigator Specifics:
Professional Details:
Publications
CV not available
Member of Section:
Clinical Research Section
Cellular and Molecular Physiology
Current Fellows, Students, or Lab Members:
Merav Baz-Hecht, MD
Aaron M Cypess, MD, PhD
Florencia Halperin, MD
Ximena Lopez, MD
Elizabeth Tatro
Past Fellows, etc.:
Waleed Aldhahi, MD, FRCPC
Rachel Bernier
Clara Bouche, MD
Emily Devine
Amy Fleischman, MD, MMSc
Sheila O'Shea
Shanti Serdy, MD
Robert Silver, MD
Jennifer Sivitz, MD
Investigators
Adjunct Investigators
Fellows & Team Members
DERC Cores
Research Sections
Joslin Resources
Allison B. Goldfine, MD
Investigator
Joslin Diabetes Center
Head Clinical Research
Joslin Diabetes Center
7/1/1989 -
Research investigations focus on clinical and molecular translational projects related to insulin action and development of type 2 diabetes and molecular mechanism of drug action. Obesity promotes a state of chronic subacute inflammation that promotes insulin resistance, type 2 diabetes, and cardiovascular disease. Thus, anti-inflammatory drugs may provide a therapeutic strategy to treat or prevent diabetes and its related vascular complications. Clinical trials are in progress using anti-inflammatory salicylates to target inflammation and evaluate safety and effectiveness for patients with diabetes, or metabolic syndrome and cardiovascular disease.
Obesity surgery promotes sustained weight loss and improves the health of patients with severe obesity. Rare patients develop a syndrome of postprandial hyperinsulinemic hypoglycemia following gastric bypass surgery. Understanding this disorder may lead to new treatment strategies for patients who suffer from repeated episodes of severe hypoglycemia or may lead to new ways to improve beta cell function for the 24 million people in the United States who have type 2 diabetes.
Additional translational studies look at the role of insulin in regulation of beta cell function. Cellular and rodent data suggest that insulin secretory beta cells themselves contain the insulin receptor and insulin signaling proteins and may represent insulin responsive tissue. Preliminary studies in humans in vivo suggest that insulin can enhance glucose-induced insulin secretion and studies are ongoing to determine if this effect is attenuated in insulin resistant or pre-diabetic persons.
Dr. Goldfine has been active on the task force to improve and increase clinical research at the Joslin Diabetes Center.
Selected References:
Goldfine AB, Bouche C, Parker RA., Kim C, Kerivan A, Soeldner JA, Martin BC, Warram JH, Kahn CR. Insulin Resistance is a Poor Predictor of Type 2 Diabetes In Individuals with No Family History of Disease. Proceedings National Academy of Science, 2003;100: 2724-2729
Aldhahi W, Mun E, Goldfine, AB. Portal and Peripheral Cortisol Levels in Obese Humans. Diabetologia, Diabetologia. 2004 May;47(5):833-6.
Aldhahi W, Armstrong J, Bouche C, Carr RD, Moses A, Goldfine AB. Beta-cell Insulin Secretory Response to Oral Hypoglycemic Agents is Blunted In Humans in vivo During Moderate Hypoglycemia, J Clin Endocrinol Metab. 2004 Sep;89(9):4553-4557
Halperin F, Beckman JA, Patti ME, Trujillo ME, Garvin M, Creager MA, Scherer PE, Goldfine AB. The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes. Diabetologia. 2005 Oct;48(10):2147-54.
Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB. Severe Hypoglycemia Post-Gastric Bypass Requiring Partial Pancreatectomy: Evidence for Inappropriate Insulin Secretion and Pancreatic Islet Hyperplasia. Diabetologia. 2005 No26.
Goldfine AB, Crunkhorn S, Costello M, Gami1 H, Landaker EJ, Niinobe M, Yoshikawa K, Kahn CR, Lo D, Warren A, Jimenez-Chillaron J, Patti ME. Necdin and E2F4 are Targets of Rosiglitazone Therapy in Diabetic Human Adipose and Muscle Tissue. Diabetes. 2006 Mar;55(3):640-50. v;48(11):2236-40.
Goldfine AB, Mun EC, Devine D, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME. Patients with Neuroglycopenia Post Gastric Bypass Surgery Have Exaggerated Incretin and Insulin Secretory Responses to Mixed Meal. J Clin Endocrinol Metab. 2007 Dec;92(12):4678-85.
Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults. Diabetes Care, 2008 Feb;31(2):289-94.
Goldfine AB, Silver S, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes, Clinical and Translational Science, 2008 May;1(1):36-43
Goldfine AB. Assessing the Cardiovascular Safety of Diabetes Therapies. New England Journal of Medicine. 2008, Sept 11, 359(11):1092-1095.
Biographical Sketch:
Dr. Goldfine is an Associate Professor in Medicine at Harvard Medical School and Head of Clinical Research at the Joslin Diabetes Center. Dr. Goldfine received her M.D. from the University of Pennsylvania School of Medicine, and completed residency training at the University of Massachusetts Medical Center. She completed a fellowship in diabetes and endocrinology at Joslin before joining the staff of the Center.
